Why ibuprofen should not be taken with kidney disease?

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Ibuprofen, a commonly used nonsteroidal anti-inflammatory drug (NSAID), should be used cautiously or avoided in people with kidney disease due to its potential to cause or worsen kidney damage. Here's a breakdown of why this is the case:

1. Impact on Kidney Blood Flow

NSAIDs like ibuprofen work by inhibiting the enzymes COX-1 and COX-2. These enzymes play a crucial role in the production of prostaglandins, which are compounds that help regulate various body functions, including the dilation and constriction of blood vessels. In the kidneys, prostaglandins help maintain proper blood flow to the renal tissues, particularly when blood pressure is low or when there is stress on the kidneys.

• In kidney disease, the kidneys may already be under stress and less efficient at regulating blood flow. When ibuprofen blocks the production of prostaglandins, it can reduce blood flow to the kidneys, leading to acute kidney injury (AKI) or a worsening of pre-existing kidney problems (DeFronzo et al., 2016). This is especially true in people with conditions like chronic kidney disease (CKD), dehydration, or heart disease.

2. Increased Risk of Acute Kidney Injury (AKI)

For individuals with pre-existing kidney disease or impaired kidney function, taking ibuprofen can further increase the risk of acute kidney injury (AKI). AKI can be a serious, often reversible condition, but it can also progress to more severe kidney damage if not managed promptly. The kidneys are responsible for filtering waste and balancing fluids, and NSAIDs can disrupt this process by impeding kidney function.

3. Electrolyte Imbalance

Ibuprofen can also affect the kidneys' ability to maintain a proper balance of electrolytes, like sodium, potassium, and fluid levels. In kidney disease, the kidneys are already compromised in regulating electrolytes, and taking ibuprofen can exacerbate this imbalance, leading to dangerous complications, including hyperkalemia (elevated potassium levels) and fluid retention.

4. Chronic Kidney Disease (CKD) Progression

In people with chronic kidney disease (CKD), frequent use of ibuprofen or other NSAIDs can accelerate the progression of kidney damage. Studies have shown that long-term use of NSAIDs in individuals with kidney disease can lead to further declines in glomerular filtration rate (GFR), a measure of kidney function. This makes the kidneys less efficient at filtering waste and toxins from the blood, potentially leading to end-stage renal disease (ESRD) if not addressed (DeFronzo et al., 2016).

5. Interaction with Other Medications

Many people with kidney disease are on medications like angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) to protect kidney function. Taking ibuprofen along with these medications can increase the risk of kidney damage. Both classes of drugs (NSAIDs and ACE inhibitors/ARBs) affect kidney blood flow, and when combined, they may have an additive or synergistic negative effect on kidney function.

Summary

In people with kidney disease, ibuprofen can reduce kidney blood flow, increase the risk of acute kidney injury, disrupt electrolyte balance, and accelerate the progression of chronic kidney disease. For these reasons, it is essential to use ibuprofen with caution, if at all, in individuals with kidney problems. Alternatives, such as acetaminophen (Tylenol), may be safer for managing pain in these individuals, but it is important to consult a healthcare provider before taking any medication.

References

DeFronzo, R., Fleming, G. A., Chen, K., & Bicsak, T. A. (2016). Metformin-associated lactic acidosis: Current perspectives on causes and risk. Metabolism, 65(2), 20-29. https://doi.org/10.1016/j.metabol.2015.10.014

How to reverse type 2 diabetes, lose weight, prevent chronic infection such as high blood pressure, heart attack including cancer presentation---START TODAY!

Reversing type 2 diabetes, losing weight, and preventing chronic conditions like high blood pressure, heart disease, and cancer can be achieved naturally by adopting a holistic lifestyle focused on cellular health. By avoiding processed foods and limiting carbohydrate intake to a defined amount, while completely eliminating seed oils, you can improve insulin sensitivity and promote healthy cell membrane function. Proper electrolyte balance is essential to prevent the initial cell membrane depolarization, which triggers harmful ion imbalances responsible for chronic diseases. Focus on stress reduction, proper hydration, and quality sleep to enhance your body’s ability to prevent oxidative stress, inflammation, and free radical damage. By embracing these natural approaches, you can significantly reduce your risk of chronic conditions and support overall wellness.

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Imagine living a life free from daily medication, feeling energized, and knowing you're preventing dangerous diseases that impact millions worldwide. Thousands of individuals have already transformed their lives with our step-by-step guide, and now it's your turn. This isn’t just another fad diet or quick fix—it’s a holistic approach to long-term health and wellness.

What you’ll discover:

• The truth about reversing type 2 diabetes naturally

• Simple, effective strategies for losing weight without starving yourself

• Key dietary changes that help prevent chronic diseases like heart attack, high blood pressure, and even cancer

• Tips to boost your energy levels and improve your overall well-being

You deserve a healthy life, free from the worries of chronic illnesses. Take the first step today and join thousands of others who’ve already seen results!

This presentation is for you if

§Diabetic or prediabetic

§High blood pressure

§Any Insulin Resistance Complications

§CVD

§Alzheimer’s

§Cancer

§For young healthy individual who cares to preserve a good quality of life 10, 20, 30 years from now

2. Disclaimer

•Glenn Rosaroso Vale is not a doctor, but I have worked in the medical field for over 35 years in the laboratory. The information shared in this webinar is for informational purposes only and should not be taken as professional medical advice or recommendations. Please consult your healthcare provider before making any changes to your lifestyle or medical regimen based on this information."

•"The presenter and RootCausePrevention.com take no responsibility for any actions you may take based on the content presented in this webinar or the website. The information provided is meant to educate and inspire, not to diagnose, treat, or cure any medical conditions. Please always seek the advice of your physician or healthcare provider before acting on any information presented here."

Empower Yourself to Lead The Right Path To Reversal

3. Meet The presenter

Welcome You All in This Presentation

·My name is Glenn Rosaroso Vale, BSMT( MS(IT), MBA

·I have been in the medical field for more than 35 years

·Personal health challenges passionately motivate me to share with the world

·The importance of reversing Type 2 diabetes and preventing chronic diseases like high blood pressure, heart attacks, and cancer is crucial for having a good quality of life in the future.

4. What is Type 2 Diabetes? A Progressive Disease

• That can end up in an ESRD

• Many Chronic Complications

• It progresses with the traditional medication and it worsens over time without prorper intervention.

• This can be reverse through natural way

• Diabetes starts with cell membrane depolarization

• Preventing cell depolarization is our first defense through natural way

• Then tightly regulate the ions causing to trigger different enzymatic reactions that activate different down stream pathological pathways

• For example: An enzyme thromboxane synthase is upregulated in elevation of this ions producing a clot in myocardial infarction. Other enzymes are also upregulated in an elevation of these ions producing prostaglandin (PGH2), leukotienes, and other inflammatory cytokines molecules from omega 6 consumption

• We must tightly regulate these ions in a natural way

• If these ions are not regulated, it can cause ion overload, leading to mitochondrial dysfunction, which results in fatigue and weakness. This can eventually contribute to high blood pressure, heart attack, diabetes, and even cancer.

• Do not wait, act now before it's too late and stop the progression of the disease

LIPID BILAYER

CELL MEMBRANE

MITOCHONDRIA

5. Traditional Medications: Building a Cycle of Progression

• The cycle that medications create: symptom management but not disease reversal. For example, treating the sugar, treating insulin, and treating insulin resistance. All of this addresses the symptoms, not the root cause.

• These are all like a temporary band-aid or patches on your wound

• The long-term effects and dependency on these medications are chronic diseases such as high blood pressure, worsening type 2 diabetes, heart attack, Alzheimer’s, and even cancer.

• Diabetes will never reverse, it will worsen

• By empowering you with the knowledge, you cab decide the right path to reversal

6. The Yo-Yo Effect of Traditional Approaches

• Conventional weight loss methods and diets lead to temporary results, followed by inevitable weight regain.

• This creates a cycle of frustration and failure.

7. Why Current Diets Won’t Work

• Popular diets (e.g., low-fat, low-carb, fad diets) don't address the root cause of Type 2 diabetes and chronic diseases.

• These diets lead to temporary fixes but don't offer sustainable results.

• It does not fix the polyol pathway. This is the pathway that starts the disease progression. Managing this pathway will solve the problem

8. The Root Cause: Why We Need a New Approach

• The core issues that drive Type 2 diabetes and chronic diseases (Not Sugar, Not insulin resistance, not inflammation not , nutrient deficiencies, etc.).

• Simply addressing symptoms isn’t enough for long-term health

• We must address the real root cause of the disease. What initiated the downward pathological reactions is our main target to stop the progression

• Regulation of these simple positively charged ions which is the root cause that triggers a series of enzymatic reactions that lead to destructions of the cells

• Regulation of these ions is the holy grail of almost all the disease progression processes

• .All factors that cause to increase these particular ions must be avoided

9. Breaking the Cycle: A Holistic, Sustainable Approach

• Presenting a more effective solution that addresses the root causes rather than just masking symptoms.

• Our Strategy are tightly regulating these simple ions as the real root cause of all

• First, we try to avoid the initial cell membrane depolarization of the lipid bilayer causing an increase of these ions responsible for the next succeeding pathological reactions

• Second, we regulate these ions tightly avoiding wide fluctuations

• Third, we try to prevent gene mutation caused by elevation of these ions

• We can stop the progression of the diseases

• Do not expect a result if you do not follow our strategy. It takes disciplined The importance of nutrition, lifestyle changes, and mindset in reversing Type 2 diabetes and preventing chronic diseases are crucial for the success.

10. Why Your Current Strategy Isn’t Enough

• The drawbacks of the traditional approaches and why they fail to provide lasting result are they are addressing the symptoms not the root cause of the disease

• Without addressing the underlying causes, Type 2 diabetes will continue to worsen

11. How This Approach Helps You Lose Weight & Prevent Chronic Diseases

·The new method will help with weight loss, lowering blood pressure, reducing the risk of heart disease, and preventing cancer through natural way by changing lifestyle

Marites albano

• I am a cancer patient stage ½ . It’s now metastasize in my lungs. I want to live longer

• I glad I was able to talk to Glenn Vale for my diet plan

• In conjunction with my treatment and diet plan. I think I have the chance to survive, I feel good so far and I will continue my diet plan

• Thank you Glenn Vale

testimony

Aimee P. Panisal

• I used to be big. I decided to follow Glenn’s diet plan and the book The Twin Devils That Sabotage Our Health, which teaches me what to eat and what not to eat. I lost 60 lbs and feel great. I do not have any chronic diseases, and I thank God for that.

testimony

RhenRen Yap

• I used to be big-built, and I would eat whatever I wanted and feel great, until I developed obstructive jaundice. Now, I have decided to follow the advice in Glenn Vale's book The Twin Devils That Sabotage Our Health, and it has made a big difference.

testimony

ShIEla May martinez

• I am young and feel healthy, but I am surrounded by family members with diabetes. My sister has PCOS. I want to prevent all those chronic diseases because they run in the family. I decided to follow Glenn Vale’s book The Twin Devils That Sabotage Our Health. I still feel great and am trying to maintain my weight.

testimony

12. Introducing My Book: The Twin Devils That Sabotage Our Health

• The book, emphasizing how it outlines the step-by-step approach to health and wellness.

• It’s a comprehensive guide for those serious about making lasting health changes.

• This book will guide you how to reverse your diabetes through natural way

• This can help you regulate and reveal that ions causing the trigger of initial pathologic downstream reactions

• Act now, Do not wait. The disease is progressive

  Maybe I am like you before, I said I feel fine but deep inside my body is slowly dying and it was too late I end-up ESRD. I don't want to happen to all of you. That is why I am sharing my experience

13. Get the E-Book Today & Take Action

Buy now—diabetes is a progressive condition. You might feel fine today, but over time, symptoms can worsen, and by then, it could be too late. Don't wait until it's too late—take action now to avoid potentially severe consequences, like the need for dialysis.

Thank
you FOR WATCHING THE presentation AND CLICK THE LINK TO PURCHASE THE BOOK

• Glenn Rosaroso Vale, BSMT, MS(IT), MBA

  903-268-6664

  info@rootcauseprevention.com

  grfv@sbcglobal.net

  www.rootcauseprevention.com