What is Alkaline Phosphatase (ALP) and What Does Its Elevation Mean?

Alkaline phosphatase (ALP) is an enzyme present in various tissues, such as the liver, bones, intestines, and kidneys, with the highest concentrations found in the epithelial cells of the bile ducts. When the bile flow is obstructed, the epithelial cells of the bile ducts release more ALP into the bloodstream. An elevated ALP is often associated with conditions that affect bile flow, such as biliary obstruction or cholestasis, where bile cannot flow normally from the liver to the intestines.

Typically, a two to three times increase in ALP suggests a bile duct obstruction or cholestasis, as opposed to liver cell damage, which would cause a more dramatic rise in hepatocellular enzymes like ALT (alanine aminotransferase) and AST (aspartate aminotransferase).

Elevated Direct Bilirubin and Its Indications

Bilirubin is a waste product generated from the breakdown of red blood cells. The liver processes and conjugates this bilirubin, making it water-soluble so it can be excreted in bile. When direct bilirubin is elevated, it signals that the liver has successfully conjugated the bilirubin, but a blockage in the bile ducts prevents it from being excreted properly.

Elevated direct bilirubin typically indicates a post-hepatic obstruction, where the blockage occurs after bilirubin has been processed by the liver, often due to conditions like:

• Gallstones

• Primary sclerosing cholangitis (PSC)

• Choledocholithiasis (gallstones in the bile duct)

• Bile duct cancers

The Role of Amylase and Lipase: The Pancreatic Enzyme Connection

Amylase and lipase are enzymes produced by the pancreas to aid in digestion, specifically for carbohydrates and fats, respectively. When there is an obstruction in the common bile duct, especially if a gallstone is involved, the bile duct and pancreatic duct are often in close proximity and can share a common opening at the ampulla of Vater.

A gallstone blocking the bile duct can also compress the pancreatic duct, leading to a backup of pancreatic enzymes (amylase and lipase) into the bloodstream. This condition is known as pancreatitis, where pancreatic enzymes leak into the surrounding tissues and cause inflammation.

Conditions Associated with Elevated ALP, Direct Bilirubin, and Pancreatic Enzyme Levels

When you see elevated levels of ALP, direct bilirubin, amylase, and lipase, it often points to conditions affecting the biliary system, especially those causing post-hepatic obstruction. Here are some key conditions to consider:

1. Gallstones (Choledocholithiasis):

   • Gallstones that migrate into the common bile duct can block bile flow, leading to elevated direct bilirubin (since conjugation is completed in the liver but excretion is blocked). ALP also rises due to bile duct obstruction. If the stone compresses the pancreatic duct, it can result in acute pancreatitis, elevating amylase and lipase.

2. Primary Sclerosing Cholangitis (PSC):

   • This chronic condition causes inflammation and scarring of the bile ducts, leading to bile flow obstruction. It can result in elevated direct bilirubin and ALP. Pancreatitis may occur due to shared duct anatomy.

3. Cholangiocarcinoma (Bile Duct Cancer):

   • Bile duct cancer can obstruct bile flow, raising direct bilirubin and ALP. If the cancer also compresses the pancreatic duct, it can cause an increase in amylase and lipase levels, indicating pancreatic involvement.

4. Bile Duct Strictures:

   • Scarring or narrowing of the bile ducts (often from surgery, trauma, or inflammatory conditions) can cause post-hepatic jaundice, with elevated ALP and direct bilirubin. If the pancreatic duct is obstructed, amylase and lipase can also rise.

Symptoms of Post-Hepatic Bile Duct Obstruction

In addition to laboratory findings, there are external manifestations that may accompany bile duct obstruction, particularly when bilirubin builds up in the bloodstream:

1. Jaundice: The yellowing of the skin and sclera (the white part of the eyes) is a key sign of elevated bilirubin.

2. Dark Urine: As bilirubin is excreted by the kidneys, it can darken urine, giving it a tea-colored appearance.

3. Pale Stools: Since bilirubin is not being excreted into the intestines, stools may appear pale or clay-colored.

4. Itching (Pruritus): The accumulation of bile salts in the skin can lead to intense itching.

5. Abdominal Pain: Especially if gallstones are involved, patients may experience pain in the upper right abdomen or radiating to the back.

6. Fever: If infection, such as cholangitis, is present, fever can be a common symptom.

Conclusion

Elevations in ALP, direct bilirubin, and pancreatic enzymes (amylase and lipase) usually indicate post-hepatic bile duct obstruction, often caused by gallstones or other conditions affecting the bile ducts. Early diagnosis and intervention are essential to prevent complications such as pancreatitis or liver damage. Imaging studies like ultrasound, CT scan, or ERCP are crucial in identifying the underlying cause of these abnormalities.

Takeaway

If you experience elevated ALP, direct bilirubin, and pancreatic enzymes, consult your healthcare provider to evaluate the possibility of bile duct obstruction. Conditions like gallstones or PSC should be investigated thoroughly, as untreated bile duct obstructions can lead to serious complications. Additionally, be mindful of external signs like jaundice and abdominal pain, which can point to underlying issues with the biliary system.

How to reverse type 2 diabetes, lose weight, prevent chronic infection such as high blood pressure, heart attack including cancer presentation---START TODAY!

Reversing type 2 diabetes, losing weight, and preventing chronic conditions like high blood pressure, heart disease, and cancer can be achieved naturally by adopting a holistic lifestyle focused on cellular health. By avoiding processed foods and limiting carbohydrate intake to a defined amount, while completely eliminating seed oils, you can improve insulin sensitivity and promote healthy cell membrane function. Proper electrolyte balance is essential to prevent the initial cell membrane depolarization, which triggers harmful ion imbalances responsible for chronic diseases. Focus on stress reduction, proper hydration, and quality sleep to enhance your body’s ability to prevent oxidative stress, inflammation, and free radical damage. By embracing these natural approaches, you can significantly reduce your risk of chronic conditions and support overall wellness.

Are you tired of battling type 2 diabetes, struggling with weight loss, or worried about the risks of chronic diseases like high blood pressure, heart attack, and even cancer? It's time to take control of your health with proven, science-backed strategies that can help you not only reverse type 2 diabetes, but also shed excess weight and protect yourself from life-threatening conditions.

Imagine living a life free from daily medication, feeling energized, and knowing you're preventing dangerous diseases that impact millions worldwide. Thousands of individuals have already transformed their lives with our step-by-step guide, and now it's your turn. This isn’t just another fad diet or quick fix—it’s a holistic approach to long-term health and wellness.

What you’ll discover:

• The truth about reversing type 2 diabetes naturally

• Simple, effective strategies for losing weight without starving yourself

• Key dietary changes that help prevent chronic diseases like heart attack, high blood pressure, and even cancer

• Tips to boost your energy levels and improve your overall well-being

You deserve a healthy life, free from the worries of chronic illnesses. Take the first step today and join thousands of others who’ve already seen results!

This presentation is for you if

§Diabetic or prediabetic

§High blood pressure

§Any Insulin Resistance Complications

§CVD

§Alzheimer’s

§Cancer

§For young healthy individual who cares to preserve a good quality of life 10, 20, 30 years from now

2. Disclaimer

•Glenn Rosaroso Vale is not a doctor, but I have worked in the medical field for over 35 years in the laboratory. The information shared in this webinar is for informational purposes only and should not be taken as professional medical advice or recommendations. Please consult your healthcare provider before making any changes to your lifestyle or medical regimen based on this information."

•"The presenter and RootCausePrevention.com take no responsibility for any actions you may take based on the content presented in this webinar or the website. The information provided is meant to educate and inspire, not to diagnose, treat, or cure any medical conditions. Please always seek the advice of your physician or healthcare provider before acting on any information presented here."

Empower Yourself to Lead The Right Path To Reversal

3. Meet The presenter

Welcome You All in This Presentation

·My name is Glenn Rosaroso Vale, BSMT( MS(IT), MBA

·I have been in the medical field for more than 35 years

·Personal health challenges passionately motivate me to share with the world

·The importance of reversing Type 2 diabetes and preventing chronic diseases like high blood pressure, heart attacks, and cancer is crucial for having a good quality of life in the future.

4. What is Type 2 Diabetes? A Progressive Disease

• That can end up in an ESRD

• Many Chronic Complications

• It progresses with the traditional medication and it worsens over time without prorper intervention.

• This can be reverse through natural way

• Diabetes starts with cell membrane depolarization

• Preventing cell depolarization is our first defense through natural way

• Then tightly regulate the ions causing to trigger different enzymatic reactions that activate different down stream pathological pathways

• For example: An enzyme thromboxane synthase is upregulated in elevation of this ions producing a clot in myocardial infarction. Other enzymes are also upregulated in an elevation of these ions producing prostaglandin (PGH2), leukotienes, and other inflammatory cytokines molecules from omega 6 consumption

• We must tightly regulate these ions in a natural way

• If these ions are not regulated, it can cause ion overload, leading to mitochondrial dysfunction, which results in fatigue and weakness. This can eventually contribute to high blood pressure, heart attack, diabetes, and even cancer.

• Do not wait, act now before it's too late and stop the progression of the disease

LIPID BILAYER

CELL MEMBRANE

MITOCHONDRIA

5. Traditional Medications: Building a Cycle of Progression

• The cycle that medications create: symptom management but not disease reversal. For example, treating the sugar, treating insulin, and treating insulin resistance. All of this addresses the symptoms, not the root cause.

• These are all like a temporary band-aid or patches on your wound

• The long-term effects and dependency on these medications are chronic diseases such as high blood pressure, worsening type 2 diabetes, heart attack, Alzheimer’s, and even cancer.

• Diabetes will never reverse, it will worsen

• By empowering you with the knowledge, you cab decide the right path to reversal

6. The Yo-Yo Effect of Traditional Approaches

• Conventional weight loss methods and diets lead to temporary results, followed by inevitable weight regain.

• This creates a cycle of frustration and failure.

7. Why Current Diets Won’t Work

• Popular diets (e.g., low-fat, low-carb, fad diets) don't address the root cause of Type 2 diabetes and chronic diseases.

• These diets lead to temporary fixes but don't offer sustainable results.

• It does not fix the polyol pathway. This is the pathway that starts the disease progression. Managing this pathway will solve the problem

8. The Root Cause: Why We Need a New Approach

• The core issues that drive Type 2 diabetes and chronic diseases (Not Sugar, Not insulin resistance, not inflammation not , nutrient deficiencies, etc.).

• Simply addressing symptoms isn’t enough for long-term health

• We must address the real root cause of the disease. What initiated the downward pathological reactions is our main target to stop the progression

• Regulation of these simple positively charged ions which is the root cause that triggers a series of enzymatic reactions that lead to destructions of the cells

• Regulation of these ions is the holy grail of almost all the disease progression processes

• .All factors that cause to increase these particular ions must be avoided

9. Breaking the Cycle: A Holistic, Sustainable Approach

• Presenting a more effective solution that addresses the root causes rather than just masking symptoms.

• Our Strategy are tightly regulating these simple ions as the real root cause of all

• First, we try to avoid the initial cell membrane depolarization of the lipid bilayer causing an increase of these ions responsible for the next succeeding pathological reactions

• Second, we regulate these ions tightly avoiding wide fluctuations

• Third, we try to prevent gene mutation caused by elevation of these ions

• We can stop the progression of the diseases

• Do not expect a result if you do not follow our strategy. It takes disciplined The importance of nutrition, lifestyle changes, and mindset in reversing Type 2 diabetes and preventing chronic diseases are crucial for the success.

10. Why Your Current Strategy Isn’t Enough

• The drawbacks of the traditional approaches and why they fail to provide lasting result are they are addressing the symptoms not the root cause of the disease

• Without addressing the underlying causes, Type 2 diabetes will continue to worsen

11. How This Approach Helps You Lose Weight & Prevent Chronic Diseases

·The new method will help with weight loss, lowering blood pressure, reducing the risk of heart disease, and preventing cancer through natural way by changing lifestyle

Marites albano

• I am a cancer patient stage ½ . It’s now metastasize in my lungs. I want to live longer

• I glad I was able to talk to Glenn Vale for my diet plan

• In conjunction with my treatment and diet plan. I think I have the chance to survive, I feel good so far and I will continue my diet plan

• Thank you Glenn Vale

testimony

Aimee P. Panisal

• I used to be big. I decided to follow Glenn’s diet plan and the book The Twin Devils That Sabotage Our Health, which teaches me what to eat and what not to eat. I lost 60 lbs and feel great. I do not have any chronic diseases, and I thank God for that.

testimony

RhenRen Yap

• I used to be big-built, and I would eat whatever I wanted and feel great, until I developed obstructive jaundice. Now, I have decided to follow the advice in Glenn Vale's book The Twin Devils That Sabotage Our Health, and it has made a big difference.

testimony

ShIEla May martinez

• I am young and feel healthy, but I am surrounded by family members with diabetes. My sister has PCOS. I want to prevent all those chronic diseases because they run in the family. I decided to follow Glenn Vale’s book The Twin Devils That Sabotage Our Health. I still feel great and am trying to maintain my weight.

testimony

12. Introducing My Book: The Twin Devils That Sabotage Our Health

• The book, emphasizing how it outlines the step-by-step approach to health and wellness.

• It’s a comprehensive guide for those serious about making lasting health changes.

• This book will guide you how to reverse your diabetes through natural way

• This can help you regulate and reveal that ions causing the trigger of initial pathologic downstream reactions

• Act now, Do not wait. The disease is progressive

  Maybe I am like you before, I said I feel fine but deep inside my body is slowly dying and it was too late I end-up ESRD. I don't want to happen to all of you. That is why I am sharing my experience

13. Get the E-Book Today & Take Action

Buy now—diabetes is a progressive condition. You might feel fine today, but over time, symptoms can worsen, and by then, it could be too late. Don't wait until it's too late—take action now to avoid potentially severe consequences, like the need for dialysis.

Thank
you FOR WATCHING THE presentation AND CLICK THE LINK TO PURCHASE THE BOOK

• Glenn Rosaroso Vale, BSMT, MS(IT), MBA

  903-268-6664

  info@rootcauseprevention.com

  grfv@sbcglobal.net

  www.rootcauseprevention.com