What is GLP-1 Semaglutide?

Semaglutide is a synthetic version of the naturally occurring GLP-1 hormone, which regulates blood glucose levels and appetite. As a GLP-1 receptor agonist, semaglutide enhances insulin secretion, reduces glucagon levels, and slows gastric emptying, helping individuals with type 2 diabetes manage blood sugar and supporting weight loss. It is approved for both diabetes and obesity treatment, with the brand names Ozempic (for diabetes) and Wegovy (for weight loss).

Benefits of GLP-1 Semaglutide Drugs

1. Improved Blood Sugar Control
   Semaglutide is highly effective in lowering HbA1c levels, the primary marker of long-term blood glucose control. It improves insulin sensitivity, reduces hepatic glucose production, and boosts insulin secretion when needed, making it an essential treatment for those with type 2 diabetes.

2. Weight Loss
   A key benefit of semaglutide is its significant impact on weight reduction. By promoting satiety and slowing gastric emptying, it helps patients consume fewer calories, resulting in a reduced body weight. This is particularly beneficial for patients struggling with obesity, a condition that often coexists with type 2 diabetes.

3. Cardiovascular Protection
   Semaglutide has been shown to reduce the risk of heart attacks, strokes, and cardiovascular deaths. For individuals with type 2 diabetes, who are at an elevated risk for cardiovascular diseases, this benefit is especially important.

4. Convenience and Efficacy
   Semaglutide is available as a once-weekly injection, offering a convenient treatment schedule. It is also available in oral form (Rybelsus), providing flexibility for patients who prefer not to inject themselves.

Potential Side Effects of GLP-1 Semaglutide

While semaglutide offers many benefits, it is not without its risks. Most side effects are gastrointestinal and include:

• Nausea

• Vomiting

• Diarrhea

• Abdominal pain

• Constipation

These side effects tend to subside over time as the body adjusts to the drug. However, there are more concerning potential complications, such as hyperplasia of adipose cells and ophthalmic disorders.

Hyperplasia of Adipose Cells and Its Implications

One of the lesser-discussed side effects of GLP-1 receptor agonists like semaglutide is hyperplasia of adipose cells. This refers to the increase in the number of fat cells, which can occur as a result of the weight loss induced by the drug.

Although semaglutide helps patients lose weight by reducing appetite and slowing gastric emptying, there is some concern that rapid or excessive weight loss could trigger adipose cell hyperplasia. This condition could contribute to the development of metabolic complications such as insulin resistance and chronic inflammation, both of which increase the risk of cardiovascular diseases. While the long-term effects of fat cell hyperplasia are still being studied, it is important for patients to be mindful of this potential risk.

Ophthalmic Complications Linked to Semaglutide: A Growing Concern

Recent research has raised alarms about the ophthalmic complications associated with semaglutide, particularly concerning the risk of vision loss. A case series published in JAMA Ophthalmology (2025) revealed that a subset of patients using semaglutide and tirzepatide experienced severe eye conditions, including nonarteritic anterior ischemic optic neuropathy (NAION) and papillitis (swelling of the optic nerve head), both of which can lead to irreversible vision loss.

Findings from the JAMA Ophthalmology Study

In a retrospective study conducted by Katz et al. (2025), a total of 9 patients (average age 57.4 years) were identified who developed significant ophthalmic complications while using either semaglutide or tirzepatide. The study found:

• Seven patients developed Nonarteritic Anterior Ischemic Optic Neuropathy (NAION), a condition that causes sudden, painless vision loss due to poor blood flow to the optic nerve.

• One patient developed papillitis, characterized by optic disc swelling and potential vision loss.

• One patient was diagnosed with paracentral acute middle maculopathy (PAMM), a rare retinal condition that can lead to distorted central vision.

The authors hypothesize that these complications may be linked to rapid correction of hyperglycemia induced by semaglutide and tirzepatide, rather than a direct toxic effect of the medications. Rapid normalization of blood glucose levels may cause fluctuations in ocular blood flow, increasing the risk of optic nerve damage. However, the study was not able to establish a causal link between the drugs and these conditions, and further research is needed to confirm these findings.

Why This Matters

For patients on semaglutide, the potential for vision loss due to these complications is a significant concern. Conditions like NAION and papillitis are typically irreversible, and patients may experience permanent vision impairment. The link between these medications and vision-threatening complications remains unclear, but healthcare providers should remain vigilant and monitor for any visual symptoms in patients receiving these drugs. Any changes in vision should be promptly addressed to avoid long-term damage.

Conclusion: The Hidden Risks of Semaglutide and Tirzepatide

While GLP-1 receptor agonists like semaglutide offer remarkable benefits in managing type 2 diabetes and obesity, vision loss and ophthalmic complications represent a growing concern. Recent studies, including a JAMA Ophthalmology case series, suggest that vision-threatening conditions, such as NAION and papillitis, may be associated with these medications, possibly due to the rapid changes in blood glucose levels they induce. Although no direct causal relationship has been proven, these findings highlight the need for careful monitoring of patients, particularly for any vision-related symptoms.

If you're considering semaglutide for diabetes or weight loss, it's crucial to discuss the potential risks with your healthcare provider, including the possibility of vision loss and the need for regular eye exams. By staying informed and vigilant, you can better manage the risks associated with these medications while benefiting from their positive effects on blood sugar control and weight management.

References

Katz, B. J., Lee, M. S., Lincoff, N. S., Abel, A. S., Chowdhary, S., Ellis, B. D., Najafi, A., Nguyen, J., Seay, M. D., & Warner, J. E. A. (2025). Ophthalmic complications associated with the antidiabetic drugs semaglutide and tirzepatide. JAMA Ophthalmology. https://doi.org/10.1001/jamaophthalmol.2024.6058people-2025-02-26/

How to reverse type 2 diabetes, lose weight, prevent chronic infection such as high blood pressure, heart attack including cancer presentation---START TODAY!

Reversing type 2 diabetes, losing weight, and preventing chronic conditions like high blood pressure, heart disease, and cancer can be achieved naturally by adopting a holistic lifestyle focused on cellular health. By avoiding processed foods and limiting carbohydrate intake to a defined amount, while completely eliminating seed oils, you can improve insulin sensitivity and promote healthy cell membrane function. Proper electrolyte balance is essential to prevent the initial cell membrane depolarization, which triggers harmful ion imbalances responsible for chronic diseases. Focus on stress reduction, proper hydration, and quality sleep to enhance your body’s ability to prevent oxidative stress, inflammation, and free radical damage. By embracing these natural approaches, you can significantly reduce your risk of chronic conditions and support overall wellness.

Are you tired of battling type 2 diabetes, struggling with weight loss, or worried about the risks of chronic diseases like high blood pressure, heart attack, and even cancer? It's time to take control of your health with proven, science-backed strategies that can help you not only reverse type 2 diabetes, but also shed excess weight and protect yourself from life-threatening conditions.

Imagine living a life free from daily medication, feeling energized, and knowing you're preventing dangerous diseases that impact millions worldwide. Thousands of individuals have already transformed their lives with our step-by-step guide, and now it's your turn. This isn’t just another fad diet or quick fix—it’s a holistic approach to long-term health and wellness.

What you’ll discover:

• The truth about reversing type 2 diabetes naturally

• Simple, effective strategies for losing weight without starving yourself

• Key dietary changes that help prevent chronic diseases like heart attack, high blood pressure, and even cancer

• Tips to boost your energy levels and improve your overall well-being

You deserve a healthy life, free from the worries of chronic illnesses. Take the first step today and join thousands of others who’ve already seen results!

This presentation is for you if

§Diabetic or prediabetic

§High blood pressure

§Any Insulin Resistance Complications

§CVD

§Alzheimer’s

§Cancer

§For young healthy individual who cares to preserve a good quality of life 10, 20, 30 years from now

2. Disclaimer

•Glenn Rosaroso Vale is not a doctor, but I have worked in the medical field for over 35 years in the laboratory. The information shared in this webinar is for informational purposes only and should not be taken as professional medical advice or recommendations. Please consult your healthcare provider before making any changes to your lifestyle or medical regimen based on this information."

•"The presenter and RootCausePrevention.com take no responsibility for any actions you may take based on the content presented in this webinar or the website. The information provided is meant to educate and inspire, not to diagnose, treat, or cure any medical conditions. Please always seek the advice of your physician or healthcare provider before acting on any information presented here."

Empower Yourself to Lead The Right Path To Reversal

3. Meet The presenter

Welcome You All in This Presentation

·My name is Glenn Rosaroso Vale, BSMT( MS(IT), MBA

·I have been in the medical field for more than 35 years

·Personal health challenges passionately motivate me to share with the world

·The importance of reversing Type 2 diabetes and preventing chronic diseases like high blood pressure, heart attacks, and cancer is crucial for having a good quality of life in the future.

4. What is Type 2 Diabetes? A Progressive Disease

• That can end up in an ESRD

• Many Chronic Complications

• It progresses with the traditional medication and it worsens over time without prorper intervention.

• This can be reverse through natural way

• Diabetes starts with cell membrane depolarization

• Preventing cell depolarization is our first defense through natural way

• Then tightly regulate the ions causing to trigger different enzymatic reactions that activate different down stream pathological pathways

• For example: An enzyme thromboxane synthase is upregulated in elevation of this ions producing a clot in myocardial infarction. Other enzymes are also upregulated in an elevation of these ions producing prostaglandin (PGH2), leukotienes, and other inflammatory cytokines molecules from omega 6 consumption

• We must tightly regulate these ions in a natural way

• If these ions are not regulated, it can cause ion overload, leading to mitochondrial dysfunction, which results in fatigue and weakness. This can eventually contribute to high blood pressure, heart attack, diabetes, and even cancer.

• Do not wait, act now before it's too late and stop the progression of the disease

LIPID BILAYER

CELL MEMBRANE

MITOCHONDRIA

5. Traditional Medications: Building a Cycle of Progression

• The cycle that medications create: symptom management but not disease reversal. For example, treating the sugar, treating insulin, and treating insulin resistance. All of this addresses the symptoms, not the root cause.

• These are all like a temporary band-aid or patches on your wound

• The long-term effects and dependency on these medications are chronic diseases such as high blood pressure, worsening type 2 diabetes, heart attack, Alzheimer’s, and even cancer.

• Diabetes will never reverse, it will worsen

• By empowering you with the knowledge, you cab decide the right path to reversal

6. The Yo-Yo Effect of Traditional Approaches

• Conventional weight loss methods and diets lead to temporary results, followed by inevitable weight regain.

• This creates a cycle of frustration and failure.

7. Why Current Diets Won’t Work

• Popular diets (e.g., low-fat, low-carb, fad diets) don't address the root cause of Type 2 diabetes and chronic diseases.

• These diets lead to temporary fixes but don't offer sustainable results.

• It does not fix the polyol pathway. This is the pathway that starts the disease progression. Managing this pathway will solve the problem

8. The Root Cause: Why We Need a New Approach

• The core issues that drive Type 2 diabetes and chronic diseases (Not Sugar, Not insulin resistance, not inflammation not , nutrient deficiencies, etc.).

• Simply addressing symptoms isn’t enough for long-term health

• We must address the real root cause of the disease. What initiated the downward pathological reactions is our main target to stop the progression

• Regulation of these simple positively charged ions which is the root cause that triggers a series of enzymatic reactions that lead to destructions of the cells

• Regulation of these ions is the holy grail of almost all the disease progression processes

• .All factors that cause to increase these particular ions must be avoided

9. Breaking the Cycle: A Holistic, Sustainable Approach

• Presenting a more effective solution that addresses the root causes rather than just masking symptoms.

• Our Strategy are tightly regulating these simple ions as the real root cause of all

• First, we try to avoid the initial cell membrane depolarization of the lipid bilayer causing an increase of these ions responsible for the next succeeding pathological reactions

• Second, we regulate these ions tightly avoiding wide fluctuations

• Third, we try to prevent gene mutation caused by elevation of these ions

• We can stop the progression of the diseases

• Do not expect a result if you do not follow our strategy. It takes disciplined The importance of nutrition, lifestyle changes, and mindset in reversing Type 2 diabetes and preventing chronic diseases are crucial for the success.

10. Why Your Current Strategy Isn’t Enough

• The drawbacks of the traditional approaches and why they fail to provide lasting result are they are addressing the symptoms not the root cause of the disease

• Without addressing the underlying causes, Type 2 diabetes will continue to worsen

11. How This Approach Helps You Lose Weight & Prevent Chronic Diseases

·The new method will help with weight loss, lowering blood pressure, reducing the risk of heart disease, and preventing cancer through natural way by changing lifestyle

Marites albano

• I am a cancer patient stage ½ . It’s now metastasize in my lungs. I want to live longer

• I glad I was able to talk to Glenn Vale for my diet plan

• In conjunction with my treatment and diet plan. I think I have the chance to survive, I feel good so far and I will continue my diet plan

• Thank you Glenn Vale

testimony

Aimee P. Panisal

• I used to be big. I decided to follow Glenn’s diet plan and the book The Twin Devils That Sabotage Our Health, which teaches me what to eat and what not to eat. I lost 60 lbs and feel great. I do not have any chronic diseases, and I thank God for that.

testimony

RhenRen Yap

• I used to be big-built, and I would eat whatever I wanted and feel great, until I developed obstructive jaundice. Now, I have decided to follow the advice in Glenn Vale's book The Twin Devils That Sabotage Our Health, and it has made a big difference.

testimony

ShIEla May martinez

• I am young and feel healthy, but I am surrounded by family members with diabetes. My sister has PCOS. I want to prevent all those chronic diseases because they run in the family. I decided to follow Glenn Vale’s book The Twin Devils That Sabotage Our Health. I still feel great and am trying to maintain my weight.

testimony

12. Introducing My Book: The Twin Devils That Sabotage Our Health

• The book, emphasizing how it outlines the step-by-step approach to health and wellness.

• It’s a comprehensive guide for those serious about making lasting health changes.

• This book will guide you how to reverse your diabetes through natural way

• This can help you regulate and reveal that ions causing the trigger of initial pathologic downstream reactions

• Act now, Do not wait. The disease is progressive

  Maybe I am like you before, I said I feel fine but deep inside my body is slowly dying and it was too late I end-up ESRD. I don't want to happen to all of you. That is why I am sharing my experience

13. Get the E-Book Today & Take Action

Buy now—diabetes is a progressive condition. You might feel fine today, but over time, symptoms can worsen, and by then, it could be too late. Don't wait until it's too late—take action now to avoid potentially severe consequences, like the need for dialysis.

Thank
you FOR WATCHING THE presentation AND CLICK THE LINK TO PURCHASE THE BOOK

• Glenn Rosaroso Vale, BSMT, MS(IT), MBA

  903-268-6664

  info@rootcauseprevention.com

  grfv@sbcglobal.net

  www.rootcauseprevention.com