Neuropathy and the Electric Shock-Like Sensation in the Feet: The Role of Sorbitol Accumulation and Calcium Imbalance

After consuming a large amount of carbohydrates, particularly in individuals with diabetes or impaired glucose regulation, it’s common to experience electric shock-like sensations in the feet, particularly in the plantar area. This sensation can be explained by a complex interplay of metabolic and cellular processes that disrupt normal nerve function.

The Mechanism Behind Neuropathy and the Electrified Sensation

1. Sorbitol Accumulation Due to High Blood Sugar: When blood glucose levels are elevated after consuming carbohydrates, the enzyme aldose reductase is upregulated, which converts glucose into sorbitol. In conditions of sustained high blood sugar, excessive sorbitol accumulates in cells, especially in nerve cells of the feet. Sorbitol is normally produced in small quantities, but its buildup due to prolonged hyperglycemia can overwhelm the normal metabolic pathways.

2. Increased Osmotic Pressure and Cellular Depolarization: Sorbitol accumulation increases the osmotic pressure inside nerve cells, drawing water into the cells. This swelling disrupts normal cellular homeostasis. As the nerve cells swell, their membranes become more excitable, leading to cellular depolarization. This depolarization triggers the activation of voltage-gated calcium channels, which increases the influx of calcium ions (Ca2+) into the cells. This is a key step in the onset of the electric shock-like sensations.

3. Intracellular Calcium Overload: The influx of calcium into the cell leads to an increase in intracellular calcium levels. The elevated calcium activates the endoplasmic reticulum (ER), which releases more calcium into the cytosol, further raising intracellular calcium levels. This creates a positive feedback loop, where more calcium enters the cell, exacerbating the problem.

   • Calcium toxicity: The excessive calcium inside the nerve cells can be toxic, particularly to the mitochondria. Elevated calcium levels disrupt mitochondrial function, impairing the cell’s ability to generate energy. This leads to cellular stress and damage. Additionally, calcium toxicity can trigger the activation of enzymes that break down cellular structures, contributing to nerve damage.

4. Hyperexcitability of Nerve Fibers: The increased intracellular calcium levels make nerve fibers hyperexcitable. This means that even minor stimuli can result in exaggerated nerve responses, such as spontaneous firing of action potentials. This is likely the cause of the electric shock-like sensations, as the nerves send abnormal, unwanted signals to the brain.

Summary of the Mechanism:

1. Carbohydrate intake increases blood glucose, leading to the upregulation of aldose reductase and subsequent conversion of glucose to sorbitol.

2. Sorbitol accumulation inside nerve cells raises osmotic pressure, causing water influx and cellular swelling.

3. The swelling leads to cellular depolarization, activating voltage-gated calcium channels, increasing the influx of calcium ions.

4. Increased calcium levels further activate the endoplasmic reticulum to release more calcium into the cytosol, creating a calcium overload.

5. Excessive calcium inside the cell can cause mitochondrial toxicity and cellular dysfunction, leading to nerve damage and hyperexcitability of nerve fibers.

6. This hyperexcitability contributes to abnormal nerve signaling, manifesting as electric shock-like sensations in the feet.

Conclusion

The electrified sensation in the feet, particularly after carbohydrate consumption, can be explained by the biochemical cascade triggered by high blood sugar levels, which causes sorbitol accumulation. This leads to osmotic changes within nerve cells, causing calcium influx and a cascade of cellular events that result in nerve dysfunction. These disturbances contribute to the abnormal sensations of burning, tingling, or electric shock-like feelings in the feet, a hallmark symptom of neuropathy. Managing blood glucose levels can help mitigate these effects and reduce the frequency of such symptoms.

How to reverse type 2 diabetes, lose weight, prevent chronic infection such as high blood pressure, heart attack including cancer presentation---START TODAY!

Reversing type 2 diabetes, losing weight, and preventing chronic conditions like high blood pressure, heart disease, and cancer can be achieved naturally by adopting a holistic lifestyle focused on cellular health. By avoiding processed foods and limiting carbohydrate intake to a defined amount, while completely eliminating seed oils, you can improve insulin sensitivity and promote healthy cell membrane function. Proper electrolyte balance is essential to prevent the initial cell membrane depolarization, which triggers harmful ion imbalances responsible for chronic diseases. Focus on stress reduction, proper hydration, and quality sleep to enhance your body’s ability to prevent oxidative stress, inflammation, and free radical damage. By embracing these natural approaches, you can significantly reduce your risk of chronic conditions and support overall wellness.

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This presentation is for you if

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2. Disclaimer

•Glenn Rosaroso Vale is not a doctor, but I have worked in the medical field for over 35 years in the laboratory. The information shared in this webinar is for informational purposes only and should not be taken as professional medical advice or recommendations. Please consult your healthcare provider before making any changes to your lifestyle or medical regimen based on this information."

•"The presenter and RootCausePrevention.com take no responsibility for any actions you may take based on the content presented in this webinar or the website. The information provided is meant to educate and inspire, not to diagnose, treat, or cure any medical conditions. Please always seek the advice of your physician or healthcare provider before acting on any information presented here."

Empower Yourself to Lead The Right Path To Reversal

3. Meet The presenter

Welcome You All in This Presentation

·My name is Glenn Rosaroso Vale, BSMT( MS(IT), MBA

·I have been in the medical field for more than 35 years

·Personal health challenges passionately motivate me to share with the world

·The importance of reversing Type 2 diabetes and preventing chronic diseases like high blood pressure, heart attacks, and cancer is crucial for having a good quality of life in the future.

4. What is Type 2 Diabetes? A Progressive Disease

• That can end up in an ESRD

• Many Chronic Complications

• It progresses with the traditional medication and it worsens over time without prorper intervention.

• This can be reverse through natural way

• Diabetes starts with cell membrane depolarization

• Preventing cell depolarization is our first defense through natural way

• Then tightly regulate the ions causing to trigger different enzymatic reactions that activate different down stream pathological pathways

• For example: An enzyme thromboxane synthase is upregulated in elevation of this ions producing a clot in myocardial infarction. Other enzymes are also upregulated in an elevation of these ions producing prostaglandin (PGH2), leukotienes, and other inflammatory cytokines molecules from omega 6 consumption

• We must tightly regulate these ions in a natural way

• If these ions are not regulated, it can cause ion overload, leading to mitochondrial dysfunction, which results in fatigue and weakness. This can eventually contribute to high blood pressure, heart attack, diabetes, and even cancer.

• Do not wait, act now before it's too late and stop the progression of the disease

LIPID BILAYER

CELL MEMBRANE

MITOCHONDRIA

5. Traditional Medications: Building a Cycle of Progression

• The cycle that medications create: symptom management but not disease reversal. For example, treating the sugar, treating insulin, and treating insulin resistance. All of this addresses the symptoms, not the root cause.

• These are all like a temporary band-aid or patches on your wound

• The long-term effects and dependency on these medications are chronic diseases such as high blood pressure, worsening type 2 diabetes, heart attack, Alzheimer’s, and even cancer.

• Diabetes will never reverse, it will worsen

• By empowering you with the knowledge, you cab decide the right path to reversal

6. The Yo-Yo Effect of Traditional Approaches

• Conventional weight loss methods and diets lead to temporary results, followed by inevitable weight regain.

• This creates a cycle of frustration and failure.

7. Why Current Diets Won’t Work

• Popular diets (e.g., low-fat, low-carb, fad diets) don't address the root cause of Type 2 diabetes and chronic diseases.

• These diets lead to temporary fixes but don't offer sustainable results.

• It does not fix the polyol pathway. This is the pathway that starts the disease progression. Managing this pathway will solve the problem

8. The Root Cause: Why We Need a New Approach

• The core issues that drive Type 2 diabetes and chronic diseases (Not Sugar, Not insulin resistance, not inflammation not , nutrient deficiencies, etc.).

• Simply addressing symptoms isn’t enough for long-term health

• We must address the real root cause of the disease. What initiated the downward pathological reactions is our main target to stop the progression

• Regulation of these simple positively charged ions which is the root cause that triggers a series of enzymatic reactions that lead to destructions of the cells

• Regulation of these ions is the holy grail of almost all the disease progression processes

• .All factors that cause to increase these particular ions must be avoided

9. Breaking the Cycle: A Holistic, Sustainable Approach

• Presenting a more effective solution that addresses the root causes rather than just masking symptoms.

• Our Strategy are tightly regulating these simple ions as the real root cause of all

• First, we try to avoid the initial cell membrane depolarization of the lipid bilayer causing an increase of these ions responsible for the next succeeding pathological reactions

• Second, we regulate these ions tightly avoiding wide fluctuations

• Third, we try to prevent gene mutation caused by elevation of these ions

• We can stop the progression of the diseases

• Do not expect a result if you do not follow our strategy. It takes disciplined The importance of nutrition, lifestyle changes, and mindset in reversing Type 2 diabetes and preventing chronic diseases are crucial for the success.

10. Why Your Current Strategy Isn’t Enough

• The drawbacks of the traditional approaches and why they fail to provide lasting result are they are addressing the symptoms not the root cause of the disease

• Without addressing the underlying causes, Type 2 diabetes will continue to worsen

11. How This Approach Helps You Lose Weight & Prevent Chronic Diseases

·The new method will help with weight loss, lowering blood pressure, reducing the risk of heart disease, and preventing cancer through natural way by changing lifestyle

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• I am a cancer patient stage ½ . It’s now metastasize in my lungs. I want to live longer

• I glad I was able to talk to Glenn Vale for my diet plan

• In conjunction with my treatment and diet plan. I think I have the chance to survive, I feel good so far and I will continue my diet plan

• Thank you Glenn Vale

testimony

Aimee P. Panisal

• I used to be big. I decided to follow Glenn’s diet plan and the book The Twin Devils That Sabotage Our Health, which teaches me what to eat and what not to eat. I lost 60 lbs and feel great. I do not have any chronic diseases, and I thank God for that.

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RhenRen Yap

• I used to be big-built, and I would eat whatever I wanted and feel great, until I developed obstructive jaundice. Now, I have decided to follow the advice in Glenn Vale's book The Twin Devils That Sabotage Our Health, and it has made a big difference.

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ShIEla May martinez

• I am young and feel healthy, but I am surrounded by family members with diabetes. My sister has PCOS. I want to prevent all those chronic diseases because they run in the family. I decided to follow Glenn Vale’s book The Twin Devils That Sabotage Our Health. I still feel great and am trying to maintain my weight.

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12. Introducing My Book: The Twin Devils That Sabotage Our Health

• The book, emphasizing how it outlines the step-by-step approach to health and wellness.

• It’s a comprehensive guide for those serious about making lasting health changes.

• This book will guide you how to reverse your diabetes through natural way

• This can help you regulate and reveal that ions causing the trigger of initial pathologic downstream reactions

• Act now, Do not wait. The disease is progressive

  Maybe I am like you before, I said I feel fine but deep inside my body is slowly dying and it was too late I end-up ESRD. I don't want to happen to all of you. That is why I am sharing my experience

13. Get the E-Book Today & Take Action

Buy now—diabetes is a progressive condition. You might feel fine today, but over time, symptoms can worsen, and by then, it could be too late. Don't wait until it's too late—take action now to avoid potentially severe consequences, like the need for dialysis.

Thank
you FOR WATCHING THE presentation AND CLICK THE LINK TO PURCHASE THE BOOK

• Glenn Rosaroso Vale, BSMT, MS(IT), MBA

  903-268-6664

  info@rootcauseprevention.com

  grfv@sbcglobal.net

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