Theoretical Aluminum Levels in Hepatitis B Vaccine: Insights from Flarend et al.'s Study. Government and Big Pharma Claim that They are in Safe Level.

Aluminum salts such as aluminum hydroxide (Al(OH)₃) and aluminum phosphate (AlPO₄) have been used for decades in vaccines as adjuvants to enhance immune responses. According to government, While vaccines have an excellent safety record, studies on aluminum absorption have raised theoretical questions about how much aluminum could enter the bloodstream, particularly in infants with small blood volumes.

Flarend et al. (1997) Study Overview

In 1997, Flarend and colleagues conducted a landmark study measuring the in vivo absorption of aluminum-containing vaccine adjuvants. They injected rabbits intramuscularly with either aluminum hydroxide (AH) or aluminum phosphate (AP), both labeled with radioactive ²⁶Al, and tracked absorption over 28 days:

• Aluminum hydroxide (AH): Approximately 17% absorbed into the blood

• Aluminum phosphate (AP): Approximately 51% absorbed into the blood

• Urinary excretion: Approximately 6% of AH dose and 22% of AP dose over 28 days

The study highlighted that different forms of aluminum dissolve at different rates, influencing how much enters systemic circulation over time (Flarend et al., 1997).

Applying Flarend’s Findings to an Infant HepB Vaccine Dose

Consider a typical Hepatitis B vaccine dose:

• Aluminum content: 250 µg per shot

• Infant blood volume: Approximately 400 mL (0.4 L)

Using Flarend’s absorption percentages, we can estimate theoretical blood aluminum concentrations if all absorbed aluminum entered the bloodstream instantly:

Aluminum TypeAbsorption (%)Aluminum entering blood (µg)Theoretical blood concentration (µg/L)Aluminum hydroxide (AH)17%42.5 µg106.25 µg/LAluminum phosphate (AP)51%127.5 µg318.75 µg/L

Comparison with Toxic Levels

For context, toxic blood aluminum levels are generally considered:

• Normal: < 5 µg/L

• At-risk / early toxicity: 60–100 µg/L

• Clearly toxic: > 100 µg/L

The theoretical calculations suggest that if all absorbed aluminum from a HepB vaccine dose entered the bloodstream at once, blood levels could exceed toxic thresholds (106 µg/L for AH, 319 µg/L for AP).

Conclusion

Flarend et al.’s study provides valuable insight into how different aluminum salts behave in vivo:

• Aluminum phosphate (AP) dissolves faster and is absorbed more readily than aluminum hydroxide (AH).

• Theoretical calculations suggest vaccine doses could reach “toxic” blood concentrations if absorbed all at once,

• Understanding absorption kinetics helps scientists design safer vaccines and set dosing limits.

Disclaimer

This blog is for informational purposes only. It does not provide medical advice. Blood levels calculated here are theoretical, based on animal studies, and do not reflect actual human infant exposure after HepB vaccination. Always consult a healthcare professional regarding vaccines or concerns about aluminum exposure.

References

Flarend, R. E., Hem, S. L., White, J. L., Elmore, D., Suckow, M. A., Rudy, A. C., & Dandashli, E. A. (1997). In vivo absorption of aluminium-containing vaccine adjuvants using ²⁶Al. Vaccine, 15(12–13), 1314–1318. https://doi.org/10.1016/S0264-410X(97)00041-8