Cancer Caused by Spike Proteins? Separating Fact from Speculation

The SARS-CoV-2 spike protein has been under intense scrutiny, not only for its role in infection but also for its potential impact on human cells. Some laboratory studies have suggested that spike protein — particularly from viral infection — can interfere with cellular pathways, including p53, a key tumor suppressor responsible for DNA repair and preventing damaged cells from turning cancerous.

These findings have understandably raised concerns: could spike protein, either from infection or vaccination, increase cancer risk? Let’s examine the evidence carefully.

Spike Protein and Cellular Effects

1. Viral Spike from Infection
   Laboratory experiments have shown that viral spike protein can interfere with pathways like p53 in cultured cancer cells. However, these studies were performed in vitro, meaning in a petri dish with cells engineered to express high levels of spike protein. Such conditions do not necessarily reflect what happens in living humans.

2. Vaccine-Derived Spike
   mRNA vaccines induce the body to produce a modified, prefusion-stabilized spike protein that differs structurally from the native viral spike. Vaccination can generate very high spike-specific antibody levels, often exceeding 25,000 units, whereas natural infection usually produces much lower levels, typically under 1,000 units. There have been no studies performed to directly assess whether spike protein generated by vaccination affects p53 function or promotes cancer in humans. however some studies claim that they found a vaccine material from the tumor cells suggesting that the spike protein from the vaccine not from infection itself are the one causing the destruction of our defense against cancer which is p53.

Antibody Levels as a Measure of Spike Exposure

• Studies measuring spike-specific IgG show that mRNA COVID-19 vaccines commonly produce antibody levels exceeding 25,000 units/mL, far higher than what is typically seen after natural infection. In contrast:

  • Normal (unexposed) individuals have antibody levels below 0.8 units/mL.

  • Levels after infection without vaccination usually reach up to 1,000 units/mL.

  • Antibody levels exceeding 2,500 units/mL are considered to carry a potential risk for immune dysregulation or other adverse effects.

  This highlights that vaccine-induced spike exposure can generate antibody levels many times higher than

The Bottom Line

We cannot definitively assign causation to infection alone; both infection and vaccination theoretically expose cells to spike protein, though the biological context is very different. Since very high spike antibody levels (>25,000 units) are more commonly observed after vaccination, it is highly probable that vaccine-induced spike exposure contributed to the observed antibody levels..

In other words, while antibody data suggest higher spike exposure from vaccines in many people, there is currently no direct evidence linking either infection-derived or vaccine-derived spike protein to cancer development in humans. Concerns remain theoretical, and further research is needed to clarify any long-term cellular effects.